Publications

You can access all our publications online via PubMed.

Pearl, J. R., Shetty, A. C., Cantle, J. P., Bergey, D. E., Bragg, R. M., Coffey, S. R., Kordasiewicz, H. B., Hood, L. E., Price, N. D., Ament, S. A., & Carroll, J. B. (2025). Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease Mouse Models. Disease Models & Mechanisms, dmm.052282. https://doi.org/10.1242/dmm.052282 Cite
Roach, J. C., Funk, C. C., Glusman, G., Merrill, D. A., Hodes, J. F., Rapozo, M. K., Edens, L., Vaidyaraman, A., Shankle, W. R., Hood, L., Bramen, J. E., & Consortium, the C. (2025). Specific plasma proteins and metabolites convey the effects of lifestyle interventions that improve cognition and function in Alzheimer’s disease. Alzheimer’s & Dementia, 20(S7), e091942. https://doi.org/10.1002/alz.091942 Cite Download
Herzog, C. M. S., Goeminne, L. J. E., Poganik, J. R., Barzilai, N., Belsky, D. W., Betts-LaCroix, J., Chen, B. H., Chen, M., Cohen, A. A., Cummings, S. R., Fedichev, P. O., Ferrucci, L., Fleming, A., Fortney, K., Furman, D., Gorbunova, V., Higgins-Chen, A., Hood, L., Horvath, S., … Gladyshev, V. N. (2024). Challenges and recommendations for the translation of biomarkers of aging. Nature Aging, 4(10), 1372–1383. https://doi.org/10.1038/s43587-024-00683-3 Cite
Swank, Z., Borberg, E., Chen, Y., Senussi, Y., Chalise, S., Manickas-Hill, Z., Yu, X. G., Alicic, R., Baxter, J., Brennan, C., Caudill, A., Chen, P., Chopra, T., Chu, H. Y., Del Alcazar, J., Duven, A. M., Edmark, R., Emerson, S., Goldman, J. D., … RECOVER Consortium. (2024). Measurement of circulating viral antigens post-SARS-CoV-2 infection in a multicohort study. Clinical Microbiology and Infection. https://doi.org/10.1016/j.cmi.2024.09.001 Cite
Hwang, Y. M., Wei, Q., Piekos, S. N., Vemuri, B., Molani, S., Mease, P., Hood, L., & Hadlock, J. (2024). Maternal-fetal outcomes in patients with immune-mediated inflammatory diseases, with consideration of comorbidities: a retrospective cohort study in a large U.S. healthcare system. EClinicalMedicine, 68, 102435. https://doi.org/10.1016/j.eclinm.2024.102435 Cite Download Download
Steinmetz, M., Minard, K., Horvath, S., McNicholast, J., Frelinger, J., Wake, C., Long, E., Mach, B., & Hood, L. (2024). Publisher Correction: A molecular map of the immune response region from the major histocompatibility complex of the mouse. Nature, 630(8016), E8–E8. https://doi.org/10.1038/s41586-023-06940-6 Cite Download
Hood, L., & Penberthy, S. (2024). “We’re Doing it Wrong!” Phenomics and Hyperscale AI for Health Care. AI in Precision Oncology, 1(1), 14–15. https://doi.org/10.1089/aipo.2023.29001.lho Cite
Piekos, S. N., Barak, O., Baumgartner, A., Chu, T., Parks, W. T., Hadlock, J., Hood, L., Price, N. D., & Sadovsky, Y. (2024). Placental Network Differences Among Obstetric Syndromes Identified With An Integrated Multiomics Approach. bioRxiv. https://doi.org/10.1101/2024.09.03.611067 Cite Download
Hwang, Y. M., Piekos, S. N., Wei, Q., Price, N. D., Hood, L., & Hadlock, J. J. (2024). Detection of Drug Effect Signals Associated with Adverse Pregnancy Outcomes Using Propensity Score Matching at Scale. medRxiv. https://doi.org/10.1101/2024.03.21.24304579 Cite Download
Ellis, D., Watanabe, K., Wilmanski, T., Lustgarten, M. S., Korat, A. V. A., Glusman, G., Hadlock, J. J., Fiehn, O., Sebastiani, P., Price, N. D., Hood, L., Magis, A. T., Evans, S. J., Pflieger, L., Lovejoy, J. C., Gibbons, S. M., Funk, C. C., Baloni, P., & Rappaport, N. (2024). APOE Genotype and Biological Age Impact Inter-Omic Associations Related to Bioenergetics. bioRxiv. https://doi.org/10.1101/2024.10.17.618322 Cite Download
Hood, L., & Price, N. (2024). The Age of Scientific Wellness: Why the Future of Medicine Is Personalized, Predictive, Data-Rich, and in Your Hands. http://journals.stfm.org/media/j4ilao5z/brbrehio0260docx-2024-01-09-22-55.pdf Cite Download
Kumari, S., Lausted, C., Scherler, K., Ng, A. H. C., Lu, Y., Lee, I., Hood, L., & Wang, K. (2024). Approaches and Challenges in Characterizing the Molecular Content of Extracellular Vesicles for Biomarker Discovery. Biomolecules, 14(12), 1599. https://doi.org/10.3390/biom14121599 Cite Download
Hwang, Y. M., Piekos, S. N., Paquette, A. G., Wei, Q., Price, N. D., Hood, L., & Hadlock, J. J. (2024). Accelerating adverse pregnancy outcomes research amidst rising medication use: parallel retrospective cohort analyses for signal prioritization. BMC Medicine, 22(1), 495. https://doi.org/10.1186/s12916-024-03717-0 Cite Download
Johnson-Martínez, J. P., Diener, C., Levine, A. E., Wilmanski, T., Suskind, D. L., Ralevski, A., Hadlock, J., Magis, A. T., Hood, L., Rappaport, N., & Gibbons, S. M. (2024). Aberrant bowel movement frequencies coincide with increased microbe-derived blood metabolites associated with reduced organ function. Cell Reports. Medicine, 5(7), 101646. https://doi.org/10.1016/j.xcrm.2024.101646 Cite
Hariharan, R., Hood, L., & Price, N. D. (2024). A data-driven approach to improve wellness and reduce recurrence in cancer survivors. Frontiers in Oncology, 14, 1397008. https://doi.org/10.3389/fonc.2024.1397008 Cite Download
Huang, Q., Hu, Z., Zheng, Q., Mao, X., Lv, W., Wu, F., Fu, D., Lu, C., Zeng, C., Wang, F., Zeng, Q., Fang, Q., & Hood, L. (2024). A Proactive Intervention Study in Metabolic Syndrome High-Risk Populations Using Phenome-Based Actionable P4 Medicine Strategy. Phenomics (Cham, Switzerland), 4(2), 91–108. https://doi.org/10.1007/s43657-023-00115-z Cite
Zhang, Y., Qin, G., Aguilar, B., Rappaport, N., Yurkovich, J. T., Pflieger, L., Huang, S., Hood, L., & Shmulevich, I. (2024). A framework towards digital twins for type 2 diabetes. Frontiers in Digital Health, 6, 1336050. https://doi.org/10.3389/fdgth.2024.1336050 Cite Download
Hwang, Y. M., Roper, R. T., Piekos, S. N., Enquobahrie, D. A., Hebert, M. F., Paquette, A. G., Baloni, P., Price, N. D., Hood, L., & Hadlock, J. J. (2024). Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events: with a consideration of the COVID-19 pandemic period. The Journal of Maternal-Fetal & Neonatal Medicine, 37(1), 2313364. https://doi.org/10.1080/14767058.2024.2313364 Cite Download
Hwang, Y.-M., Piekos, S., Sorensen, T., Hood, L., & Hadlock, J. (2023). Adoption of a National Prophylactic Anticoagulation Guideline for Hospitalized Pregnant Women With COVID-19: Retrospective Cohort Study. JMIR Public Health and Surveillance, 9, e45586. https://doi.org/10.2196/45586 Cite
Roach, J. C., Rapozo, M. K., Hara, J., Glusman, G., Lovejoy, J., Shankle, W. R., Hood, L., & COCOA Consortium: (2023). A Remotely Coached Multimodal Lifestyle Intervention for Alzheimer’s Disease Ameliorates Functional and Cognitive Outcomes. Journal of Alzheimer’s Disease: JAD, 96(2), 591–607. https://doi.org/10.3233/JAD-230403 Cite
Hwang, Y. M., Wei, Q., Piekos, S. N., Vemuri, B., Molani, S., Mease, P., Hood, L., & Hadlock, J. J. (2023). Maternal-fetal outcomes in patients with immune mediated inflammatory diseases, with consideration of comorbidities: a retrospective cohort study in a large U.S. healthcare system. MedRxiv: The Preprint Server for Health Sciences, 2023.08.07.23293726. https://doi.org/10.1101/2023.08.07.23293726 Cite Download
Rappaport, N., Ellis, D., Watanabe, K., Wilmanski, T., Hood, L., Price, N., Funk, C., & Baloni, P. (2023). BIOLOGICAL AGING AND APOE STATUS REWIRE INTER-OMIC ASSOCIATIONS RELATED TO BIOENERGETICS IN HUMANS. Innovation in Aging, 7(Suppl 1), 631–632. https://doi.org/10.1093/geroni/igad104.2058 Cite Download
Yurkovich, J. T., Evans, S. J., Rappaport, N., Boore, J. L., Lovejoy, J. C., Price, N. D., & Hood, L. E. (2023). The transition from genomics to phenomics in personalized population health. Nature Reviews. Genetics. https://doi.org/10.1038/s41576-023-00674-x Cite
Hood, L., & Penberthy, S. (2023). “We’re Doing it Wrong!” Phenomics and Hyperscale AI for Health Care. AI in Precision Oncology, 6–7. https://doi.org/10.1089/aipo.2023.29001.lho Cite Download
Barak, O., Lovelace, T., Piekos, S., Chu, T., Cao, Z., Sadovsky, E., Mouillet, J.-F., Ouyang, Y., Parks, W. T., Hood, L., Price, N. D., Benos, P. V., & Sadovsky, Y. (2023). Integrated unbiased multiomics defines disease-independent placental clusters in common obstetrical syndromes. BMC Medicine, 21(1), 349. https://doi.org/10.1186/s12916-023-03054-8 Cite
Piekos, S. N., Hwang, Y. M., Roper, R. T., Sorensen, T., Price, N. D., Hood, L., & Hadlock, J. J. (2023). Effect of COVID-19 vaccination and booster on maternal-fetal outcomes: a retrospective cohort study. The Lancet. Digital Health, 5(9), e594–e606. https://doi.org/10.1016/S2589-7500(23)00093-6 Cite Download
Huang, Y. L., Dickerson, L. K., Kenerson, H., Jiang, X., Pillarisetty, V., Tian, Q., Hood, L., Gujral, T. S., & Yeung, R. S. (2023). Organotypic Models for Functional Drug Testing of Human Cancers. BME Frontiers, 4, 0022. https://doi.org/10.34133/bmef.0022 Cite Download
Muhie, S., Gautam, A., Misganaw, B., Yang, R., Mellon, S. H., Hoke, A., Flory, J., Daigle, B., Swift, K., Hood, L., Doyle, F. J., Wolkowitz, O. M., Marmar, C. R., Ressler, K., Yehuda, R., Hammamieh, R., & Jett, M. (2023). Integrated analysis of proteomics, epigenomics and metabolomics data revealed divergent pathway activation patterns in the recent versus chronic post-traumatic stress disorder. Brain, Behavior, and Immunity, 113, 303–316. https://doi.org/10.1016/j.bbi.2023.07.015 Cite Download
Watanabe, K., Wilmanski, T., Baloni, P., Robinson, M., Garcia, G. G., Hoopmann, M. R., Midha, M. K., Baxter, D. H., Maes, M., Morrone, S. R., Crebs, K. M., Kapil, C., Kusebauch, U., Wiedrick, J., Lapidus, J., Pflieger, L., Lausted, C., Roach, J. C., Glusman, G., … Rappaport, N. (2023). Lifespan-extending interventions induce consistent patterns of fatty acid oxidation in mouse livers. Communications Biology, 6(1), 768. https://doi.org/10.1038/s42003-023-05128-y Cite
Heilig, R., Eckenberg, R., Petit, J.-L., Fonknechten, N., Da Silva, C., Cattolico, L., Levy, M., Barbe, V., de Berardinis, V., Ureta-Vidal, A., Pelletier, E., Vico, V., Anthouard, V., Rowen, L., Madan, A., Qin, S., Sun, H., Du, H., Pepin, K., … Weissenbach, J. (2023). Publisher Correction: The DNA sequence and analysis of human chromosome 14. Nature. https://doi.org/10.1038/s41586-023-06403-y Cite
Muhie, S., Gautam, A., Yang, R., Misganaw, B., Daigle, B. J., Mellon, S. H., Flory, J. D., Abu-Amara, D., Lee, I., Wang, K., Rampersaud, R., PTSD Systems Biology Consortium, Hood, L., Yehuda, R., Marmar, C. R., Wolkowitz, O. M., Ressler, K. J., Doyle, F. J., Hammamieh, R., & Jett, M. (2023). Molecular signatures of post-traumatic stress disorder in war-zone-exposed veteran and active-duty soldiers. Cell Reports. Medicine, 4(5), 101045. https://doi.org/10.1016/j.xcrm.2023.101045 Cite Download
Watanabe, K., Wilmanski, T., Diener, C., Earls, J. C., Zimmer, A., Lincoln, B., Hadlock, J. J., Lovejoy, J. C., Gibbons, S. M., Magis, A. T., Hood, L., Price, N. D., & Rappaport, N. (2023). Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention. Nature Medicine, 29(4), 996–1008. https://doi.org/10.1038/s41591-023-02248-0 Cite Download
Fang, H., Chen, L., Hood, L., & Tian, Q. (2023). Editorial: Translational phenomics and its applications in immunotherapy. Frontiers in Immunology, 14, 1211704. https://doi.org/10.3389/fimmu.2023.1211704 Cite Download
Hwang, Y. M., Roper, R. T., Piekos, S. N., Enquobahrie, D. A., Hebert, M. F., Paquette, A. G., Baloni, P., Price, N. D., Hood, L., & Hadlock, J. J. (2023). Timing of selective serotonin reuptake inhibitor use and risk for preterm birth and related adverse events. medRxiv. https://doi.org/10.1101/2023.03.03.23286717 Cite Download
Johnson, J. P., Diener, C., Levine, A. E., Wilmanski, T., Suskind, D. L., Ralevski, A., Hadlock, J., Magis, A. T., Hood, L., Rappaport, N., & Gibbons, S. M. (2023). Generally-healthy individuals with aberrant bowel movement frequencies show enrichment for microbially-derived blood metabolites associated with impaired kidney function. bioRxiv. https://doi.org/10.1101/2023.03.04.531100 Cite Download
Piekos, S. N., Price, N. D., Hood, L., & Hadlock, J. J. (2022). The impact of maternal SARS-CoV-2 infection and COVID-19 vaccination on maternal-fetal outcomes. Reproductive Toxicology (Elmsford, N.Y.), S0890-6238(22)00153-8. https://doi.org/10.1016/j.reprotox.2022.10.003 Cite Download
Diener, C., Dai, C. L., Wilmanski, T., Baloni, P., Smith, B., Rappaport, N., Hood, L., Magis, A. T., & Gibbons, S. M. (2022). Genome-microbiome interplay provides insight into the determinants of the human blood metabolome. Nature Metabolism, 4(11), 1560–1572. https://doi.org/10.1038/s42255-022-00670-1 Cite Download
Baloni, P., Arnold, M., Buitrago, L., Nho, K., Moreno, H., Huynh, K., Brauner, B., Louie, G., Kueider-Paisley, A., Suhre, K., Saykin, A. J., Ekroos, K., Meikle, P. J., Hood, L., Price, N. D., Alzheimer’s Disease Metabolomics Consortium, Doraiswamy, P. M., Funk, C. C., Hernández, A. I., … Kaddurah-Daouk, R. (2022). Multi-Omic analyses characterize the ceramide/sphingomyelin pathway as a therapeutic target in Alzheimer’s disease. Communications Biology, 5(1), 1074. https://doi.org/10.1038/s42003-022-04011-6 Cite Download
Watanabe, K., Wilmanski, T., Diener, C., Zimmer, A., Lincoln, B., Hadlock, J. J., Lovejoy, J. C., Magis, A. T., Hood, L., Price, N. D., & Rappaport, N. (2022). Multiomic investigations of Body Mass Index reveal heterogeneous trajectories in response to a lifestyle intervention. medRxiv. https://doi.org/10.1101/2022.01.20.22269601 Cite Download
Hood, L. (2022). P4 Medicine & What 21st Century Medicine Should Be. SSF Neurosurgery Grand Rounds. https://digitalcommons.psjhealth.org/publications/5700 Cite
Baloni, P., Nho, K., Arnold, M., Louie, G., Kueider-Paisley, A., Saykin, A. J., Ekroos, K., Funk, C., Hood, L., Price, N. D., Baillie, R., Kastenmüller, G., Han, X., & Kaddurah-Daouk, R. F. (2022). Investigating the importance of acylcarnitines in Alzheimer’s disease. Alzheimer’s & Dementia, 17(S3), e056647. https://doi.org/10.1002/alz.056647 Cite Download
Watanabe, K., Wilmanski, T., Baloni, P., Robinson, M., Garcia, G. G., Hoopmann, M. R., Midha, M. K., Baxter, D. H., Maes, M., Morrone, S. R., Crebs, K. M., Kapil, C., Kusebauch, U., Wiedrick, J., Lapidus, J., Lovejoy, J. C., Magis, A. T., Lausted, C., Roach, J. C., … Rappaport, N. (2022). Systems-level patterns in biological processes are changed under prolongevity interventions and across biological age. medRxiv. https://doi.org/10.1101/2022.07.11.22277435 Cite Download
Roach, J. C., Hara, J., Fridman, D., Lovejoy, J. C., Jade, K., Heim, L., Romansik, R., Swietlikowski, A., Phillips, S., Rapozo, M. K., Shay, M. A., Fischer, D., Funk, C., Dill, L., Brant-Zawadzki, M., Hood, L., & Shankle, W. R. (2022). The Coaching for Cognition in Alzheimer’s (COCOA) trial: Study design. Alzheimer’s & Dementia (New York, N. Y.), 8(1), e12318. https://doi.org/10.1002/trc2.12318 Cite Download
Roach, J. C., Edens, L., Markewych, D. R., Rapozo, M. K., Hara, J., Glusman, G., Funk, C., Bramen, J., Baloni, P., Shankle, W. R., & Hood, L. (2022). A multimodal intervention for Alzheimer’s disease results in multifaceted systemic effects reflected in blood and ameliorates functional and cognitive outcomes. medRxiv. https://doi.org/10.1101/2022.09.27.22280385 Cite Download
Wilmanski, T., Kornilov, S. A., Diener, C., Conomos, M. P., Lovejoy, J. C., Sebastiani, P., Orwoll, E. S., Hood, L., Price, N. D., Rappaport, N., Magis, A. T., & Gibbons, S. M. (2022). Heterogeneity in statin responses explained by variation in the human gut microbiome. Med (New York, N.Y.), 3(6), 388-405.e6. https://doi.org/10.1016/j.medj.2022.04.007 Cite Download
Heath, L., Earls, J. C., Magis, A. T., Kornilov, S. A., Lovejoy, J. C., Funk, C. C., Rappaport, N., Logsdon, B. A., Mangravite, L. M., Kunkle, B. W., Martin, E. R., Naj, A. C., Ertekin-Taner, N., Golde, T. E., Hood, L., Price, N. D., & Alzheimer’s Disease Genetics Consortium. (2022). Manifestations of Alzheimer’s disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90. Scientific Reports, 12(1), 6117. https://doi.org/10.1038/s41598-022-09825-2 Cite Download
Omenn, G. S., Magis, A. T., Price, N. D., & Hood, L. (2022). Personal Dense Dynamic Data Clouds Connect Systems Biomedicine to Scientific Wellness. Methods in Molecular Biology (Clifton, N.J.), 2486, 315–334. https://doi.org/10.1007/978-1-0716-2265-0_15 Cite
Roach, J. C., Hodes, J. F., Funk, C. C., Shankle, W. R., Merrill, D. A., Hood, L., & Bramen, J. (2022). Dense data enables 21th century clinical trials. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 8(1), e12297. https://doi.org/10.1002/trc2.12297 Cite Download
Piekos, S. N., Roper, R. T., Hwang, Y. M., Sorensen, T., Price, N. D., Hood, L., & Hadlock, J. J. (2022). The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study. The Lancet. Digital Health, 4(2), e95–e104. https://doi.org/10.1016/S2589-7500(21)00250-8 Cite Download