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Researchers at the Institute for Systems Biology argue that combining systems biology, longitudinal multiomics data, and artificial intelligence could transform healthcare from reactive treatment to proactive prevention, enabling scientists and clinicians to detect early molecular signs of disease and intervene before symptoms appear.

The prize recognizes foundational discoveries about regulatory T cells and the FOXP3 gene that redefined immune tolerance and opened avenues to treat autoimmune disease, enable transplantation, and advance immuno-oncology. ISB celebrates Dr. Brunkow’s leadership and collaborative science.

Discussing Super Agers, Drs. Eric Topol and Lee Hood connected breakthroughs in genomics, AI, and lifestyle science to the pursuit of longer, healthier lives.

The pioneering work of Mary Brunkow and Fred Ramsdell began with a mysterious mutant mouse known as “scurfy,” leading them to identify the FOXP3 gene and unlock how regulatory T cells prevent autoimmune disease — discoveries that now point to new treatments in cancer and autoimmunity.

ISB Co-founder Dr. Leroy (Lee) Hood has been named one of the inaugural recipients of the Michael Sela Prize in Biomedical Sciences, awarded by the Weizmann Institute of Science. Hood shares the honor with Dr. Francis S. Collins and Dr. Eric S. Lander for pioneering work that has reshaped modern medicine and advanced human health.

Postdoctoral fellows are the lifeblood of research institutions, yet their contributions are often underrecognized. At the Institute for Systems Biology (ISB), postdocs enter the scientific workforce with passion, vision, and advanced training – bringing the fresh ideas that fuel discovery.